Chapter 17 — Toward Whole-Cell Modeling

Chapter 17

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Based on: Karr et al. (2012) Cell 150:389–401 — first whole-cell model of Mycoplasma genitalium (28 submodels) · Orth et al. (2010) Nature Biotechnology 28:245–248 — Flux Balance Analysis (S·v=0, linear programming) · Bunne et al. (2024) Cell 189:3728–3748 — AI Virtual Cell (universal representations across modalities) · Warburg (1956) Science — aerobic glycolysis in cancer cells · Kierans & Taylor (2021) J. Physiology — HIF-1α regulation of glycolysis (GLUT1, HK2, LDHA, PDK1)